When she was first introduced, Tsunade was cynical of anyone with dreams, especially those who want to become Hokage. After meeting Naruto, she realises that this cynicism is insulting to the memories of both Dan and Nawaki. After seeing Naruto's conviction to become Hokage and proving her wrong in his ability to learn the Rasengan, she has a change of heart. Despite her still blunt attitude towards Naruto, she has come to care for him deeply and puts her faith in him for the future, even agreeing to take on the mantle of Hokage herself, carrying on the dreams of Dan and Nawaki. As Hokage, Tsunade has shown the same level of loyalty to the village that previous Hokage held; during the invasion of Pain, she released all of her chakra in order to save the lives of thousands of people within Konoha, at great personal risk. Tsunade also has a great deal of faith in the next generation, and sees the potential that Naruto and the rest of the Konoha 11 hold.
Tsunade typically projects a tough demeanour, even when facing great personal difficulty. She readily criticises others for their faults, such as Naruto's immaturity or Jiraiya's perversion, though her habits are rarely any better. Another trait of Tsunade is her monsterous, quick temper and many fear her because of this, such as Shizune, Jiraiya, and Sakura. Beneath this tough exterior, Tsunade truly loves her village and its people and will at times show sympathy for others, consoling Shikamaru that, while he failed his mission to return Sasuke to Konoha, all of his team-mates survived. This is also shown when she worked hard in order to help heal Rock Lee, so that he might continue to be a ninja. In life-threatening or important situations that involve putting someone she cares for in danger, she tends to get angry with people who disagree with her plan, such as the restrictions the Konoha Elders placed on Naruto, or the argument on whether Naruto and Killer B should participate in the Fourth Shinobi World War, even calling Gaara a "child" when he disagreed with her. As with all Hokage before her, Tsunade deeply believes in the Will of Fire.
Tsunade also has a firm belief that Naruto, and all jinchūriki, are people rather than instruments of war. She has always voiced that Naruto is a great ninja and should be used by the village as any other ninja would be. This value is so strong in Tsunade that she yelled at the other Kage for not allowing Naruto and Killer B to fight in the Fourth Great Shinobi War. Although she eventually agrees to keep the jinchūriki away from the battles, she is outraged when A decides to kill Naruto to prevent him entering the war. Tsunade then turns on A, saying that they need to use the jinchūriki in the war if they are going to win. This shows her great faith in Naruto to end the war, as she was even willing to challenge the Raikage in order to let Naruto and B pass.
Tsunade is also a compulsive gambler with a losing streak due to her terrible luck. As a result, she has been elevated to a comical status as "The Legendary Sucker"(伝説のカモ, Densetsu no Kamo) because of the gross profits others have made off of her misfortune and gambling addiction. In the rare instances that Tsunade hits a winning streak, seeing it as a bad omen that eventually effects her or her comrades afterwards. The symbol on the back of her coat, 賭 (kake) means "gamble", or "wager", as gambling is one of her favourite pastimes.
Despite Tsunade shunning all of Jiraiya's romantic advances over the years, as she was still in love with Dan even after his death, she still cared very much for him as one of her oldest friends. While he was in Amegakure investigating Pain, she bets that he will die so that her terrible luck will ensure he survives. When she finds out he has died, she thinks back on their time together and mourns privately for the loss of her dear friend.
Tsunade is a fairly tall, light-skinned woman with light golden-amber eyes and straight blonde hair. Her hair is waist-length with shoulder-length bangs framing both sides of her face. As a child, she had it tied in a high ponytail. As an adult, it is usually tied into two loose ponytails. Some time after leaving the village, she obtained a violet rhombus mark on her forehead similar to her grandmother's, which she uses as a chakra gathering point known as the Yin Seal. It will temporarily disappear when unleashing the conserved chakra and reappear after she has accumulated enough chakra.
While only in her early fifties, her form is a frail and wrinkled old appearance, more so than her age would suggest. However, she maintains the appearance of her younger self through a unique and constant Transformation Technique. In her youth, the appearance she normally takes, she had a slender yet noticeably curvaceous frame. Despite being known as flat-chested in her childhood, she now has a rather large bust; 106 centimetres in circumference, according to Jiraiya. Her beauty has been pointed out several times and she's been called the most beautiful kunoichi in the world by several characters.
She often wears a grass-green robe with the kanji for gamble(賭, kake) written in black on the back, inside a red circle. Underneath she wears a grey, kimono-style blouse with no sleeves, held closed by a broad, dark bluish-grey obi that matches her pants. Her blouse is closed quite low, revealing her sizeable cleavage. She wears open-toed sandals with high heels and red polish on both her fingernails and toenails. She also wears a soft pink lipstick. She also used to wear the First Hokage's Necklace in clear view on her chest, before giving it to Naruto. When she releases the Yin Seal, the diamond mark on her forehead opens out into a seal that usually extends to her jaws. When using the Strength of a Hundred Technique, the markings extend themselves around her entire body.